Hivon_P Sorry for the delay in responding. We've received your Unity project and confirmed we can reproduce the issue.
Our Unity expert @Harald will provide a detailed response later, but it appears the fact that your skeleton's texture is split across three pages may be related.
Your skeleton's texture atlas was composed of three 2048 * 2048px pages. Packing it to fit within a single page with a page size limit of 4096 * 4096px seems to resolve this issue.
As a general note unrelated to this specific issue, it's advisable to pack textures onto a single atlas page whenever possible, unless absolutely necessary. This helps reduce unnecessary draw calls. In your skeleton's case, the order of the three texture atlas pages didn't seem to match the rendering order, leading to a configuration with many draw calls:

This point is mentioned in the following section of the documentation, so please review it:
spine-unity 运行时文档 渲染 #Material切换和绘制调用