lingxi If you haven't read it yet, please take a look at the Runtime Skins page of the Spine Runtimes Guide. This will give you a general idea of what you can do at runtime:
https://esotericsoftware.com/spine-runtime-skins
This guide applies to all Spine Runtimes.
Depending on the runtime you use, however, there may be more convenient solutions. For instance, the Spine-Unity Runtime has a useful package that simplifies texture on-demand loading:
https://esotericsoftware.com/spine-unity-on-demand-loading
